Thermo Fisher Scientific SERPINB9 Monoclonal Antibody (PI9-17)
SERPINB9 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체. Western blot 및 IHC에 사용 가능하며, 인간 시료에 반응. Granzyme B 억제 연구 및 세포사멸 관련 연구에 적합. 비결합형 액상 형태로 4°C 보관.
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Applications
Western Blot (WB)
- Assay-dependent
Immunohistochemistry (IHC)
- 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PI9-17 |
| Immunogen | Recombinant human full-length PI9 (proteinase inhibitor 9) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Tissue culture supernatant with 0.7% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2301633 |
Product Specific Information
The human intracellular serpin proteinase inhibitor 9 (PI9) is the only human protein able to inhibit the activity of the serine protease granzyme B. Granzyme B is expressed by cytotoxic lymphocytes and induces rapid target cell apoptosis. PI9-17 monoclonal antibody was selected after immunization with full-length recombinant PI9 produced in Escherichia coli. No cross-reactivity with other homologous serpins (PI6, PI8, and PAI-2) was observed.
Target Information
PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995 [PubMed 8530382]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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