Thermo Fisher Scientific RORB Monoclonal Antibody (OTI1C11), TrueMAB
RORB 단백질을 인식하는 Mouse monoclonal antibody로, Western blot에 최적화되어 있습니다. Human 시료에 반응하며, 고순도의 affinity chromatography로 정제되었습니다. PBS/BSA/glycerol buffer에 보관되며, -20°C에서 안정적으로 저장 가능합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–260 of human RORB produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Retinoid-related orphan receptor beta (RORβ), a NR1 thyroid hormone receptor, is involved in the development and function of the central nervous system, including sensory input integration and circadian timing. Disruption of RORβ in mice results in juvenile ataxia, retinal degeneration, circadian activity abnormalities, and delayed onset of male fertility.
RORβ binds to monomeric response elements containing the sequence AnnTAGGTCA as a monomer.
An alternatively spliced isoform, RORβ2, has been isolated from rats, with expression confined to the pineal gland and retina. RORβ2 shares DNA- and ligand-binding domains with wild-type RORβ but has a distinct amino-terminal domain.
RORβ expression has been documented in various regions of the mouse brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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