Thermo Fisher Scientific RORB Monoclonal Antibody (OTI4B7), TrueMAB
인간 RORB 단백질(아미노산 1-260)에 특이적인 마우스 단클론 항체. Western blot에 최적화된 TrueMAB 형식. 액상형, 1 mg/mL 농도, PBS/BSA/glycerol 버퍼 포함. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–260 of human RORB produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Retinoid-related orphan receptor beta (RORβ), a NR1 thyroid hormone receptor, affects development and functioning of the central nervous system, including sensory input integration and circadian timing.
Disruption of RORβ in mice results in juvenile ataxia, retinal degeneration, circadian activity abnormalities, and delayed onset of male fertility.
RORβ binds to monomeric response elements containing the sequence AnnTAGGTCA as a monomer.
An alternatively spliced isoform, RORβ2, has been isolated from rats; its expression is confined to the pineal gland and retina.
RORβ2 shares common DNA- and putative ligand-binding domains with wild-type RORβ but has a distinct amino-terminal domain.
RORβ expression has been documented in various regions of the mouse brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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