Thermo Fisher Scientific Alpha A Crystallin Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
KHNERQDDHGY ISREFHRRYR LPSNVDQSAL SCSLSADGML TFCGPKIQTG LDATHAERAI PVSREEKPTS A

• Highest antigen sequence identity: Mouse 92%, Rat 92%

Target Information

Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue.
In the lens, their structural function is to maintain the proper refractive index. The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma.

• Alpha-crystallin: Largest class, composed of two gene products—alpha-A and alpha-B
• Beta-crystallin: Comprises at least five different proteins
• Gamma-crystallin: Monomeric, with at least five identified in bovine and rat lens

Alpha-crystallin accounts for approximately 40% of total lens protein composition.
It functions as a molecular chaperone, preventing protein aggregation that can lead to cataract formation.
Phosphorylation of alpha-crystallin may occur under cellular stress, contributing to structural control and protein maintenance.
Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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