Thermo Fisher Scientific CDK8 Polyclonal Antibody
CDK8 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간 CDK8의 N-말단 합성 펩타이드로부터 제작되었습니다. 0.5 mg/mL 농도의 액상 형태이며, PBS(2% sucrose)와 sodium azide를 포함합니다. -20°C에서 보관합니다.
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Applications
- Western Blot (WB): 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal region of human CDK8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2691371 |
Product Specific Information
This target displays homology in the following species:
Dog: 100%; Guinea Pig: 75%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Target Information
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 belongs to the cyclin-dependent kinase (CDK) family, which are critical regulators of cell cycle progression.
The prototype member p34/Cdc2 and related protein Cdk2 function late in the cycle, while Cdk4 and Cdk6 are involved in G1 to S phase progression.
By analogy with yeast Cdk8, it is proposed that human Cdk8-Cyclin C may interact with RNA polymerase, influencing transcription mechanisms involved in cell division.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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