Thermo Fisher Scientific BCAR3 Polyclonal Antibody
BCAR3 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 다클론 항체. Western blot에서 검증됨. 마우스 반응성, 비결합형 액상 형태로 제공. TBS 버퍼(pH 7.3, 0.5% BSA) 내 0.02% sodium azide 포함. -20°C 보관, 동결/해동 반복은 피해야 함.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (RKLEPPPVKQAEL) corresponding to the C-terminus amino acids of BCAR3 (aa 816–820) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10983831 |
Product Specific Information
- Predicted to react with bovine, canine, human, and porcine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers can progress to become anti-estrogen resistant.
Breast cancer anti-estrogen resistance gene 3 (BCAR3) was identified during the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells.
The BCAR3 protein contains a putative Src homology 2 (SH2) domain, a hallmark of cellular tyrosine kinase signaling molecules, and shows partial homology to the cell division cycle protein CDC48.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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