Thermo Fisher Scientific Kir3.4 (KCNJ5) Polyclonal Antibody
Rabbit polyclonal antibody targeting human Kir3.4 (KCNJ5). Validated for IHC-P. Recombinant protein immunogen, antigen affinity purified. Supplied as liquid in PBS with 40% glycerol, stored at 4°C or -20°C. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KCNJ5 (Kir3.4). Recombinant protein control fragment (Product # RP-90942) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642936 |
Product Specific Information
Immunogen sequence:
TPVLTLEKGF YEVDYNTFHD TYETNTPSCC AKELAEMKRE GRLLQYLPSP PLLGGCAEAG LDAEAEQNEE DEPKGLGG
Sequence identity:
- Mouse: 88%
- Rat: 85%
Target Information
G protein–coupled inwardly rectifying potassium channels (Kir3.1–Kir3.4) are coupled to multiple neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex, and thalamus.
Also known as GIRK channels, Kir3 proteins localize to the soma, dendrites, and axons of neurons. Gβγ subunits from G protein heterotrimers bind directly to Kir3 cytoplasmic domains, modulating channel activity. Gβ3- and Gβ4-containing dimers enhance K⁺ current, while Gβ5-containing dimers inhibit it. Kir3 activity is also inhibited by tyrosine phosphorylation, which can be induced by brain-derived neurotrophic factor (BDNF) through receptor tyrosine kinase B activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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