Thermo Fisher Scientific Phospho-NFkB-p105 (Ser907) Polyclonal Antibody
NFkB p105 단백질의 Ser907 인산화 부위를 인식하는 폴리클로날 항체로, Western blot 및 IHC 분석에 적합. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 액상 형태. 세포 성장 및 염증 관련 NF-kB 신호 연구용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence that includes phosphorylation site of Serine 907 (P-L-S(p)-P-A) derived from human NFκB-p105 and conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | Dulbecco’s PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NF-κB is a nuclear transcription factor activated by various extracellular and intracellular stimuli such as cytokines, UV radiation, stress, injury, and microbial products. It regulates cellular processes including growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50) is a 50 kDa functional subunit of NF-κB, belonging to the Rel protein family. It is synthesized as a p105 precursor containing an N-terminal RHD region with nuclear localization, DNA-binding, and dimerization domains. NFKB1 (p50) forms homodimers or heterodimers with p65 to create the active NF-κB complex, which translocates to the nucleus and binds DNA. Dysregulation of NF-κB has been implicated in AIDS, cancer metastasis, and rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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