Thermo Fisher Scientific PDGFR beta Recombinant Rabbit Monoclonal Antibody (BLR081G)
Recombinant rabbit monoclonal antibody recognizing human PDGFR beta (CD140b). Validated for WB, ICC/IF, Flow Cytometry, and IP. High purity, unconjugated liquid form, suitable for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100 – 1:500 |
| Flow Cytometry (Flow) | 1 µL per 1 × 10⁶ cells |
| Immunoprecipitation (IP) | 6 µL / 1 mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR081G |
| Immunogen | Recombinant protein representing the extracellular domain of human Platelet Derived Growth Factor Receptor beta (residues 33–532) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1000 µg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 7.8–8.6 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Target Information
PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor forms a homodimer or a heterodimer, composed of both PDGFR alpha and beta polypeptides. The PDGFRB gene is located on chromosome 5, adjacent to the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all potentially associated with the 5-q syndrome. A translocation between chromosomes 5 and 12, fusing PDGFRB (CD140b) to the ETV6 leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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