Thermo Scientific™

MPBH (4-(4-N-maleimidophenyl)butyric acid hydrazide)

Thermo Scientific Pierce MPBH is a long, maleimide-and-hydrazide crosslinker for conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as자세히 알아보기

Thermo Scientific Pierce MPBH is a long, maleimide-and-hydrazide crosslinker for conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).

Features of MPBH:

• Reactive groups: maleimide and hydrazide
• Reactive towards: sulfhydryl groups and carbonyl (aldehyde) groups
• Long (17.9A), sulfhydryl-to-aldehyde crosslinker with an aromatic ring in its spacer arm (noncleavable)
• Maleimide group reacts with sulfhydryl groups to form stable thioether linkages
• Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates
• Use sodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups
• Use with EDC to conjugate primary amine of hydrazide group to carboxyl groups

Product References:
Crosslinker Application Guide -- search for recent literature references for this product

Related Products
BMPH
EMCH
KMUH

사양

화학물질 반응성Carbohydrate-Sulfhydryl

CleavableNo

설명MPBH

분자량309.75

페길레이티드No

스페이서 암 길이17.9 Å

세포 투과성Yes

배송 조건Ambient

제품라인Pierce™

라벨링 방법Chemical Labeling

교차결합제 유형Heterobifunctional

반응성 부분Amine, Hydrazide, Maleimide

스페이서Medium (10 to 30 Å)

형태Powder

수량50 mg

용해도DMF, DMSO

형식Standard

수용성No

제품 유형Crosslinker

Unit SizeEach