Thermo Scientific™

GMBS (N-γ-maleimidobutyryl-oxysuccinimide ester)

Thermo Scientific Pierce GMBS is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a자세히 알아보기

Thermo Scientific Pierce GMBS is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a short spacer arm (7.3 angstroms).

Features of GMBS:

• Reactive groups: NHS ester and maleimide
• Reactive toward: amino and sulfhydryl groups
• C4-homolog of aliphatic spacer series which includes AMAS, BMPS, GMBS and EMCS
• NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
• Maleimides react with -SH groups at pH 6.5-7.5, forming stable thioether linkages
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO); compare to Sulfo-GMBS
• Short aliphatic spacer has low potential for eliciting an immune response

Product References:
Crosslinker Application Guide -- search for recent literature references for this product

사양

화학물질 반응성Amine-Sulfhydryl

CleavableNo

설명GMBS

분자량280.23

페길레이티드No

스페이서 암 길이7.3 Å

세포 투과성Yes

배송 조건Ambient

제품라인Pierce™

라벨링 방법Chemical Labeling

교차결합제 유형Heterobifunctional

반응성 부분Maleimide, NHS Ester

스페이서Short (<10 Å)

형태Powder

수량50 mg

용해도DMF, DMSO

형식Standard

수용성No

제품 유형Crosslinker

Unit SizeEach