Thermo Fisher Scientific ST2 Monoclonal Antibody (10)

Applications

• ELISA (ELISA): Tested dilution 1:250–1:2,000

Product Specifications

Product Specific Information

• Specificity: Human IL1RL1/IL1R4

Target Information

IL-33R, also known as ST2, is a receptor for IL-33 and a member of the IL-1 receptor family of innate immune receptors. Its extracellular domain includes three Ig-like domains that interact with co-receptor IL-1RAcP and the ligand IL-33. Upon IL-33 binding, the IL-33R complex associates with adaptor proteins such as MyD88, IRAK1, IRAK4, and TRAF6, leading to activation of NF-κB and MAPK pathways. This signaling induces the release of chemokines and cytokines including IL-5, IL-6, IL-8, and IL-13.
Two main isoforms exist: ST2L (membrane-bound) and ST2S (soluble). The membrane-bound form can be released via proteolytic cleavage, while soluble forms may act as decoys to modulate IL-33 signaling.
IL-33R is primarily expressed by mast cells, basophils, and eosinophils, and in mice, also by ILC2 and Th2 cells. IL-33R signaling has been implicated in various immune-related conditions such as allergies, arthritis, atherosclerosis, and sepsis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.