Thermo Fisher Scientific ST2 Monoclonal Antibody (12)
Human IL1RL1/IL1R4(ST2) 단백질을 인식하는 mouse monoclonal antibody로 ELISA에 적합. Recombinant human IL1RL1/IL1R4 protein을 면역원으로 사용. Protein A로 정제된 액상 형태, PBS 버퍼에 보존제 없음. -20°C 보관, 연구용 전용.
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Applications
- ELISA (ELISA)
Tested Dilution: 1:1,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 12 |
| Immunogen | Recombinant human IL1RL1/IL1R4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2912114 |
Product Specific Information
Specificity: Human IL1RL1/IL1R4
Target Information
IL-33R, also known as ST2, is a receptor for IL-33 and a member of the IL-1 receptor family. Its extracellular domain contains three Ig-like domains that interact with its co-receptor IL-1RAcP and the ligand IL-33. IL-33 binding activates the NF-kB and MAPK pathways via adaptor proteins MyD88, IRAK1, IRAK4, and TRAF6, leading to the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13.
Two major isoforms, ST2L (membrane-bound) and ST2S (soluble), arise from alternative splicing. The soluble form acts as a decoy receptor, modulating IL-33 signaling. IL-33R is mainly expressed in mast cells, basophils, and eosinophils, and in mice, on ILC2 and Th2 cells. IL-33R signaling has been linked to immune conditions including allergies, arthritis, atherosclerosis, and sepsis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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