Thermo Fisher Scientific SAV1 Monoclonal Antibody (OTI2B7), TrueMAB
인간 SAV1 단백질(aa 167-383)에 특이적인 마우스 단클론 항체로 Western blot에 최적화됨. Hippo 신호 경로 연구용으로 적합하며, 액상 형태로 1 mg/mL 농도 제공. PBS/BSA/glycerol 버퍼에 보관하며 -20°C에서 안정적으로 유지.
- 카탈로그번호
- TA804764
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 167–383 of human SAV1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway, which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
The core of this pathway consists of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylate and activate LATS1/2 with MOB1. These, in turn, phosphorylate and inactivate YAP1 and WWTR1/TAZ.
Phosphorylation of YAP1 by LATS1/2 inhibits its nuclear translocation, thereby regulating genes involved in cell proliferation, death, and migration. SAV1 is essential for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues.
It also regulates centrosome disjunction by controlling NEK2 localization and its phosphorylation of CROCC and CEP250. Together with STK3/MST2, Sav1 activates ESR1 transcriptional activity through phosphorylation modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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