Thermo Fisher Scientific ING4 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

The ING4 gene belongs to the ING (Inhibitor of Growth) family of tumor suppressors. Members of this family contain a conserved plant homeodomain (PHD) finger motif at the C-terminal end, commonly found in transcription factors that modulate chromatin structure. ING proteins form transcriptional complexes that activate genes involved in cellular functions such as growth arrest, DNA repair, gene transcription, apoptosis, and senescence.

ING4 plays a role in brain tumor pathogenesis and regulates tumor growth and angiogenesis. Its expression is reduced in gliomas compared to normal brain tissue, correlating with tumor progression. ING4 interacts with the p65 (RelA) subunit of NF-κB and represses transcription of NF-κB responsive genes. Inactivating mutations and deletions of the ING4 locus have been observed in various human cancer cell lines, including 10–20% of breast cancer cell lines and tumors.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.