Thermo Fisher Scientific CD81/TAPA-1 Recombinant Mouse Monoclonal Antibody (rC81, 3442)
CD81/TAPA-1 단백질을 인식하는 재조합 마우스 단클론 항체로, Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, HEK293 세포에서 발현된 IgG1 항체입니다. 연구용으로만 사용 가능합니다.
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- 975-MSM3-P1ABX
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.5–1 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rC81, 3442 |
| Immunogen | Recombinant full-length human CD81 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris Buffer with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min. - Western Blot: 1–2 µg/mL for 2 hours at room temperature.
Target Information
CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family expressed on most nucleated cells, especially germinal center B cells.
It forms complexes with tetraspanin proteins, integrins, coreceptors, and MHC molecules, influencing adhesion, morphology, activation, proliferation, and differentiation of immune cells.
In muscle tissue, CD81 promotes cell fusion and myotube maintenance.
It also acts as a receptor for the hepatitis C virus.
CD81 and related tetraspanins (CD9, CD37, CD53, CD63, CD82) are cell-surface proteins with four hydrophobic domains that mediate signal transduction in cell development and motility.
Antibodies to CD81 have anti-proliferative effects on lymphoid cell lines, particularly large cell lymphomas.
CD81 is located in a tumor-suppressor gene region and is a candidate gene for malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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