Thermo Fisher Scientific PTPRN Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.5–1.5 µg/mL
• Publications: N/A

Product Specifications

Product Specific Information

• This antibody is predicted to react with human and rat based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 16,000.

Target Information

IA-2 (insulinoma-associated protein 2, ICA512, PTPRN) is a member of the transmembrane protein tyrosine phosphatase (PTP) family located in secretory granules of neuroendocrine cells.
The IA-2 protein is 979 amino acids long and includes luminal, transmembrane, and cytoplasmic domains.
Although a PTP family member, IA-2 lacks phosphatase activity due to amino acid substitutions at critical sites in its PTP domain.
IA-2 and IA-2β are major autoantigens in type 1 diabetes mellitus. Upon granule exocytosis, the IA-2 cytoplasmic domain is cleaved and the resulting fragment moves into the nucleus, enhancing phosphorylated STAT5 and STAT3 levels, thereby inducing insulin gene transcription and granule biogenesis.
IA-2 signaling promotes pancreatic β-cell proliferation by regulating cyclins D through STATs.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.