Thermo Fisher Scientific SDHB (Succinate Dehydrogenase B) (Pheochromocytoma Marker) Monoclonal Antibody (SDHB/2126)
SDHB 단백질을 표적하는 Thermo Fisher Scientific의 단클론 항체로, 인간 시료에 반응합니다. Western blot 및 면역조직화학(IHC)에 적합하며, 단백질 A/G로 정제된 액상 형태입니다. 미토콘드리아 복합체 II 연구 및 신경내분비종양 표지자 분석에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1.0 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SDHB/2126 |
| Immunogen | Recombinant human SDHB fragment around aa 165–273 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Complex II of the respiratory chain is specifically involved in the oxidation of succinate, carrying electrons from FADH to CoQ. The complex consists of four nuclear-encoded subunits localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, supporting a link between mitochondrial dysfunction and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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