Thermo Fisher Scientific UGGT1 Polyclonal Antibody
Rabbit polyclonal antibody against human UGGT1, reactive with human, mouse, and rat. Validated for WB and IHC(P). Supplied as liquid, unconjugated, purified by antigen affinity chromatography. Recommended for ER protein folding studies.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human UGGT1 (amino acids 583–721; UniProt ID: Q9NYU2-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649246 |
Product Specific Information
Immunogen sequence:
KVKVEHVVSV LEKKYPYVEV NSILGIDSAY DRNRKEARGY YEQTGVGPLP VVLFNGMPFE REQLDPDELE TITMHKILET TTFFQRAVYL GELPHDQDVV EYIMNQPNVV PRINSRILTA ERDYLDLTAS NNFFVDDYA
Highest antigen sequence identity to the following orthologs:
- Mouse: 94%
- Rat: 95%
Target Information
UDP-glucose:glycoprotein glucosyltransferase (UGGT) is a 170 kDa lumenal endoplasmic reticulum (ER) resident protein that catalyzes monoglucosylation of high mannose oligosaccharides. UGGT catalyzes the transfer of glucose from UDP-glucose to Man7-9GlcNAc2 moiety of unfolded glycoproteins in a Ca²⁺-dependent reaction. UGGT binds unfolded glycoprotein via two elements on its substrate: an N-acetylglucosamine unit on the oligosaccharide and hydrophobic amino acids exposed in the denatured conformation. It is postulated that UGGT serves as a sensor distinguishing between folded and denatured proteins in the ER.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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