Thermo Fisher Scientific ROBO3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.5–1 µg/mL
• View 1 publication

Product Specifications

Product Specific Information

This antibody is predicted to react with bovine, canine, and porcine species based on sequence homology.

Target Information

ROBO3 is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation.
ROBO proteins belong to the immunoglobulin transmembrane receptor superfamily. SLIT proteins (1–3) serve as ligands for ROBO proteins, and SLIT/ROBO interactions regulate processes such as myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, vasculogenesis, and neurogenesis.

ROBO3 features:

• 5 immunoglobulin (Ig)-like loops
• 3 fibronectin (Fn) type III motifs
• Transmembrane segment
• Cytoplasmic tail with three conserved signaling motifs (CC0, CC2, CC3) — lacks CC1 motif found in other ROBO family members.

ROBO3 regulates axonal navigation at the ventral midline of the neural tube.
In mice, loss of Robo3 causes commissural axons to fail crossing the midline throughout the spinal cord and hindbrain.
Mutations in ROBO3 are associated with horizontal gaze palsy with progressive scoliosis (HGPPS), an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of corticospinal and somatosensory axon tracts to cross the medulla midline.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.