Thermo Fisher Scientific p130Cas Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–3 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 5–10 µg/mL

Product Specifications

Product Specific Information

• This antibody is expected to recognize reported isoforms 1, 2, 3, 5, 6, and 7.
• Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signals via v-Crk and v-Src oncoproteins.
It has a unique structure containing an SH3 domain followed by multiple YXXP motifs and a proline-rich region.
p130Cas is involved in various biological processes including:

• Cell adhesion and migration
• Growth factor stimulation
• Cytokine receptor engagement
• Bacterial infection

Physiological functions include cardiovascular development, actin filament assembly, and Src-induced cell transformation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.