Thermo Fisher Scientific SPACA3 Polyclonal Antibody
Human SPACA3 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. SPACA3 관련 생식 및 암 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,500–1:5,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SPACA3. Recombinant protein control fragment (Product # RP-93286) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2647767 |
Product Specific Information
Immunogen sequence:
TNNGIFQINS RRWCSNLTPN VPNVCRMYCS DLLNPNLKDT VICAMKITQE PQGLGYWEAW RHHCQGKDLT EWVDGCDF
Highest antigen sequence identity to orthologs:
- Mouse: 76%
- Rat: 74%
Target Information
SPACA3 (sperm acrosome associated 3), also known as sperm lysozyme-like protein 1, lysozyme-like protein 3, ALLP-17, CT54, LYC3, SPRASA, or LYZL3, is a 215 amino acid protein involved in sperm-egg membrane adhesion and fusion during fertilization.
Identified as a novel cancer/testis antigen in hematologic malignancies, SPACA3 can elicit B-cell immune responses in cancer patients and is considered a potential immunotherapy target.
A member of the glycosyl hydrolase 22 family, SPACA3 is expressed in testis, placenta, and epididymis, existing as two alternatively spliced isoforms:
- Isoform 1: Single-pass type II membrane protein of the sperm acrosome
- Isoform 2: Secreted protein
SPACA3 may act as a receptor for the egg oligosaccharide residue N-acetylglucosamine, aiding sperm-egg fusion. The processed form shows no detectable bacteriolytic activity in vitro.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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