Thermo Fisher Scientific Erpd/Arp37 Polyclonal Antibody

Thermo Fisher Scientific ErpD/Arp37 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at 4°C prior to restoration.
• For extended storage, aliquot contents and freeze at -20°C or below.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.
• Directed against and shows specific reactivity for Borrelia burgdorferi ErpD protein.
• Reactivity with ErpD/Arp37 protein from other sources has not been determined.

Target Information

Erp proteins from Borrelia burgdorferi are postulated to be lipoproteins based on predicted amino acid sequences. The spirochete migrates from the tick midgut during feeding to the salivary glands and is transmitted to the mammal host. This transition may be facilitated by changes in expression of some B. burgdorferi genes.

It is believed that expression of various proteins associated with the spirochete may be regulated by:

• Tick life cycle changes
• Conditions during tick feeding (temperature, pH, nutrients)
• Coordination with the course of mammalian infection

Studies show that infected humans and animals produce antibodies against Erp proteins within 2–4 weeks of infection, indicating Erp synthesis during early vertebrate infection. Surface-exposed Erp proteins may facilitate interactions with host tissues during infection establishment.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.