Thermo Fisher Scientific MST1 (STK4) Polyclonal Antibody
Thermo Fisher Scientific MST1 (STK4) Polyclonal Antibody는 인간, 마우스, 랫트에 반응하며 Western blot 및 IHC에 적합합니다. 세포 내 MST1 단백질을 검출하며, Hippo 신호 경로 및 세포사멸 연구에 활용됩니다. 고순도 친화 크로마토그래피 정제 및 안정한 액상 형태로 제공됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
- Publications: [References not provided]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human MST1 (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913334 |
Product Specific Information
- Positive Control: HepG2 cell lysate, THP-1 cell lysate, rat kidney tissue, human spleen tissue, human placenta tissue, mouse testis tissue
- Subcellular Location: Cytoplasm, Nucleus
Target Information
STK4 (MST1) is a serine/threonine kinase involved in apoptosis. This protein may induce chromatin condensation during apoptosis. Following caspase cleavage, STK4 translocates to the nucleus, promoting chromatin condensation and internucleosomal DNA fragmentation.
It is a key component of the Hippo signaling pathway, crucial for organ size control and tumor suppression by limiting proliferation and promoting apoptosis.
Within this pathway, STK3/MST2 and STK4/MST1, complexed with SAV1, phosphorylate and activate LATS1/2 with MOB1. LATS1/2 then phosphorylate and inactivate YAP1 and WWTR1/TAZ, preventing their nuclear translocation and regulating genes associated with proliferation, cell death, and migration.
STK3/MST2 and STK4/MST1 are essential for repressing mature hepatocyte proliferation, preventing activation of adult liver stem cells (oval cells), and inhibiting tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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