Thermo Fisher Scientific ALDH3A1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (82%), Rat (83%), Dog (91%), Bovine (89%).
• Positive Control: Mouse eye, Whole Cornea.
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Aldh3A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes.
Aldh3A1 is highly expressed in the stomach and even more strongly in the cornea, representing between 5 to 50% of the water-soluble protein fraction in mammalian corneas.
It is thought that Aldh3A1 acts to protect the cornea from UV-induced oxidative stress by detoxifying reactive aldehydes and through the direct absorption of UV energy.
However, corneas from Aldh3A1- mice are indistinguishable from those from wild-type mice; mice lacking both Aldh3A1 and Aldh1A1 showed increased cataract formation following UVB exposure, suggesting that Aldh1A1 may compensate for the loss of Aldh3A1.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.