Thermo Fisher Scientific ALDH3A1 Polyclonal Antibody
ALDH3A1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 IHC(F)에서 사용 가능. 인간, 생쥐, 소 등 반응성. 항원 친화 크로마토그래피로 정제되었으며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human aldehyde dehydrogenase 3A1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.61 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792476 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (82%), Rat (83%), Dog (91%), Bovine (89%).
- Positive Control: Mouse eye, Whole Cornea.
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Aldh3A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes.
Aldh3A1 is highly expressed in the stomach and even more strongly in the cornea, representing between 5 to 50% of the water-soluble protein fraction in mammalian corneas.
It is thought that Aldh3A1 acts to protect the cornea from UV-induced oxidative stress by detoxifying reactive aldehydes and through the direct absorption of UV energy.
However, corneas from Aldh3A1- mice are indistinguishable from those from wild-type mice; mice lacking both Aldh3A1 and Aldh1A1 showed increased cataract formation following UVB exposure, suggesting that Aldh1A1 may compensate for the loss of Aldh3A1.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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