Thermo Fisher Scientific JMJD1A Polyclonal Antibody
JMJD1A 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 높은 특이성과 재현성을 갖추었으며, 인간 및 설치류 등 다양한 종에 반응. 항원 친화 크로마토그래피로 정제된 액상 시약.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:500–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to an internal region of the human JMJD1A protein (within residues 250–400) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.53 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 30% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11152364 |
Product Specific Information
The target sequence has 91% sequence homology with rat.
Target Information
JMJD1A is a histone demethylase that specifically demethylates Lys-9 of histone H3, playing a central role in the histone code. It preferentially demethylates mono- and dimethylated H3 Lys-9 residues, with weak or no activity on trimethylated H3 Lys-9. Demethylation generates formaldehyde and succinate.
JMJD1A is involved in hormone-dependent transcriptional activation by recruitment to androgen-receptor target genes, resulting in H3 Lys-9 demethylation and transcriptional activation. It also plays a role in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1, which are required for sperm chromatin packaging and condensation. Additionally, JMJD1A contributes to obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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