Thermo Fisher Scientific SERPINB7 Polyclonal Antibody
Human, Mouse, Rat에 반응하는 SERPINB7 폴리클로날 항체로 Western blot에 적합. 합성 펩타이드(aa 157-202)를 면역원으로 제작. 항원 친화 크로마토그래피로 정제된 고순도 항체. PBS/glycerol 완충액에 보관하며 연구용으로만 사용.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 157–202 of Human SERPINB7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2719259 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% (by SDS-PAGE).
Target Information
Megsin, also designated SerpinB7 and TP55, is a 380 amino acid cytoplasmic protein predominantly expressed in mesangial cells, which are important for maintaining glomerular structure and function. As a member of the serpin family, megsin acts as a serine protease inhibitor that potentially inactivates MMP-2, MMP-9, and plasmin—enzymes responsible for extracellular matrix degradation. Overexpression of megsin leads to mesangial cell proliferation and mesangial matrix expansion accompanied by immune complex deposition. This suggests megsin plays a key role in renal structure regulation and may be implicated in various nephropathies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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