Thermo Fisher Scientific SLC39A2 Polyclonal Antibody
SLC39A2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 적합합니다. Human 시료 반응성이 있으며, Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관하며, 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SLC39A2 (Accession Q9NP94), corresponding to amino acid residues A14–M64 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818676 |
Product Specific Information
Antibody detects endogenous levels of total ZIP2.
Target Information
The zinc transporter ZIP2, also known as SLC39A2, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP3, ZIP2− mice show no phenotypic differences compared to wild-type mice. However, when ZIP1, ZIP2, and ZIP3 genes are all eliminated and the mice are fed a zinc-deficient diet, abnormalities such as reduced embryonic membrane-bound alkaline phosphatase activity and abnormal development occur. This indicates that ZIP1–3 proteins play important, noncompensatory roles under zinc deficiency. Recent studies also show that ZIP2 and ZIP3 are downregulated in human prostate adenocarcinomatous glands and may be important in zinc retention within the cellular compartment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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