ELK Biotechnology Cav pan α1 rabbit pAb
Cav pan α1 단백질을 인식하는 토끼 폴리클로날 항체로, IHC 및 IF에 적합합니다. 세포막 및 시냅스 부위의 Cav1.2 단백질 검출에 유용하며, 고순도의 IgG 형태로 제공됩니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
Cav pan α1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2) |
| Applications | IHC; IF |
| Recommended Dilutions | IHC 1:100–200 |
| Immunogen | Synthetic Peptide of Cav pan α1 (AA range: 1288–1338) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 160–240 kD |
| Gene ID (Human) | 775 |
| Human Swiss-Prot No. | Q13936 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein; Cell membrane, sarcolemma; Perikaryon; Cell junction, synapse, postsynaptic density membrane; Cell projection, dendrite; Cell membrane, sarcolemma, T-tubule. Colocalizes with ryanodine receptors in distinct clusters at the junctional membrane, where the sarcolemma and the sarcoplasmic reticulum are in close contact. The interaction between RRAD and CACNB2 promotes the expression of CACNA1C at the cell membrane. |
| Species Reactivity | Human; Rat; Mouse |
Background
Calcium voltage-gated channel subunit alpha1 C (CACNA1C), Homo sapiens
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of these proteins, either encoded by different genes or produced by alternative splicing. The encoded protein binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins, some of which may not produce functional ion channel subunits.
(Information provided by RefSeq, Oct 2012)
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