
ELK Biotechnology AMPKβ2 rabbit pAb
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| Product name: | AMPKβ2 rabbit pAb |
| Alternative Names: | PRKAB2; 5`-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2 |
| Applications: | WB |
| Recommended Dilutions: | WB: 1:1000-2000 |
| Immunogen: | Recombinant Protein of AMPKβ2 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Observed Band: | 30kD |
| GeneID(Human): | 5565 |
| Human Swiss-Prot No: | O43741 |
| Cellular localization: | nucleoplasm,cytosol,nucleotide-activated protein kinase complex, |
| Background: | The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013], |
| Species Reactivity: | Human;Mouse;Rat |
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