ELK Biotechnology Kv1.8 rabbit pAb
Kv1.8 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF 실험에 적합합니다. 세포막 단백질 검출에 유용하며, 고농도(1 mg/ml)로 제공됩니다. 인공 펩타이드 면역원으로 제작되어 높은 특이성과 재현성을 제공합니다.
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Kv1.8 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Kv1.8 rabbit pAb |
| Alternative Names | Potassium voltage-gated channel subfamily A member 10 (Voltage-gated potassium channel subunit Kv1.8) |
| Applications | WB; IHC; IF |
| Recommended Dilutions | WB 1:1000–2000, IHC 1:100–200 |
| Immunogen | Synthetic Peptide of Kv1.8 (AA range: 194–244) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 58 kD |
| GeneID (Human) | 3744 |
| Human Swiss-Prot No | Q16322 |
| Cellular Localization | Membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes—shaker, shaw, shab, and shal—have been identified in Drosophila, each with human homologs.
This gene encodes a member of the voltage-gated, shaker-related potassium channel subfamily. It contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. Specifically regulated by cGMP, it is postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless and clustered with genes KCNA.
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