ELK Biotechnology MeCP2 rabbit pAb
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| Product name: | MeCP2 rabbit pAb |
| Alternative Names: | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) |
| Applications: | WB |
| Recommended Dilutions: | WB: 1:2000 |
| Immunogen: | Synthetic Peptide of MeCP2 AA range: 313-363 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Observed Band: | 53kD |
| GeneID（Human）: | 4204 |
| Human Swiss-Prot No: | P51608 |
| Cellular localization: | Nucleus . Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. . |
| Background: | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor |
| Species Reactivity: | Human |
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