ELK Biotechnology TBP rabbit pAb

제품명

TBP rabbit pAb

제품 개요

이 항체는 TATA-box-binding protein(TBP)을 인식하는 토끼 폴리클로날 항체입니다. TBP는 RNA polymerase II 전사 개시 복합체의 핵심 구성 요소로, 전사 조절 및 프로모터 인식에 중요한 역할을 합니다.

제품 정보

Background

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals.
TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors (TAFs). TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition, or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation.
This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus, which modulates the DNA binding activity of the protein.