ELK Biotechnology TLR1 rabbit pAb
TLR1 단백질을 인식하는 토끼 폴리클로날 항체로, IHC 및 IF 분석에 적합합니다. 세포막 및 소기관 내 위치 연구에 활용되며, 인체 및 마우스, 랫트 시료에 반응합니다. -20°C에서 장기 보관 가능합니다.
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제품명
TLR1 rabbit pAb
제품 개요
TLR1은 선천면역에서 병원체 인식에 중요한 역할을 하는 Toll-like receptor 패밀리 단백질입니다. 본 항체는 TLR1 단백질을 특이적으로 인식하는 토끼 폴리클로날 항체로, IHC 및 IF 실험에 활용할 수 있습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | TLR1 rabbit pAb |
| Alternative Names | TLR1; KIAA0012; Toll-like receptor 1; Toll/interleukin-1 receptor-like protein; TIL; CD281 |
| Applications | IHC; IF |
| Recommended Dilutions | IHC: 1:200–500 |
| Immunogen | Recombinant Protein of TLR1 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Gene ID (Human) | 7096 |
| Human Swiss-Prot No. | Q15399 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Cytoplasmic vesicle, phagosome membrane; Membrane raft; Golgi apparatus. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon microbial ligand presence. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, determining intracellular targeting to the Golgi apparatus. |
Background
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) expressed on infectious agents and mediate cytokine production necessary for effective immunity. This gene is ubiquitously expressed at higher levels than other TLR genes. Different transcript lengths may result from alternative polyadenylation sites and/or splicing.
[Provided by RefSeq, Jul 2008]
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