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ELK Biotechnology TLR2 rabbit pAb
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TLR2 rabbit polyclonal antibody로 사람, 마우스, 랫트 시료에 반응. IHC 및 IF 실험에 적합하며, 세포막 및 소포막에 위치한 TLR2 단백질 검출에 사용. 병원체 인식 및 선천 면역 연구에 활용 가능.
- 카탈로그번호
- ES20606-xxxxx (2개 옵션)
- 판매단위
- pk
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다회원가입 없이 바로 구매하세요
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ELK Biotechnology ES20606-100UL TLR2 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES20606-50UL TLR2 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology TLR2 rabbit pAb
제품명
TLR2 rabbit pAb
공급업체
ELK Biotechnology
제품 설명
TLR2 rabbit polyclonal antibody는 Toll-like receptor 2 단백질을 인식하는 항체로, 병원체 인식 및 선천 면역 반응 연구에 사용됩니다. TLR2는 세포막 단백질로서 미생물 유래 PAMPs를 인식하고 면역 반응을 활성화하는 데 중요한 역할을 합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Product name | TLR2 rabbit pAb |
| Alternative Names | TLR2; TIL4; Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD282 |
| Applications | IHC; IF |
| Recommended Dilutions | IHC: 1:200–500 |
| Immunogen | Recombinant Protein of TLR2 |
| Host | Rabbit |
| Storage | −20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| GeneID (Human) | 7097 |
| Human Swiss-Prot No | O60603 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon microbial ligand presence. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited to lipid rafts, determining intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers. |
| Background | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface receptor that can form heterodimers with other TLR family members to recognize pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins and has been implicated in autoimmune disease pathogenesis. Alternative splicing results in multiple transcript variants. [RefSeq, Jan 2016] |
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