ELK Biotechnology MSLN rabbit pAb
Human MSLN 단백질을 인식하는 rabbit polyclonal antibody로, WB, ELISA, IHC에 적합합니다. 세포막 및 골지체에 위치한 MSLN 단백질 검출에 활용되며, 다양한 종(Human, Rat, Mouse)에 반응합니다. -20°C에서 1년 보관 가능합니다.
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제품명
MSLN rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Mesothelin (CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form] |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–1:20000 |
| Immunogen | Synthesized peptide derived from human MSLN |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 10232 |
| Human Swiss-Prot No | Q13421 |
| Cellular Localization | Cell membrane; Lipid-anchor (GPI-anchor); Golgi apparatus; [Megakaryocyte-potentiating factor]: Secreted; [Isoform 3]: Secreted |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin.
Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes.
Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein.
This protein is overexpressed in epithelial mesotheliomas, ovarian cancers, and specific squamous cell carcinomas.
Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
[provided by RefSeq, Feb 2016]
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