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ELK Biotechnology Acrogranin rabbit pAb
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인간 Acrogranin을 인식하는 토끼 폴리클로날 항체로 WB 및 ELISA에 적합. 세포 내 리소좀 및 분비 경로 연구에 활용 가능. GRN 결함 관련 신경퇴행성 질환 연구에 유용. 고순도 IgG, 1 mg/ml 농도.
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ELK Biotechnology ES20288-100UL Acrogranin rabbit pAb, 100UL pk판매 단위 pk ·
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ELK Biotechnology ES20288-50UL Acrogranin rabbit pAb, 50UL pk판매 단위 pk ·
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ELK Biotechnology · ELK Biotechnology Acrogranin rabbit pAb
Acrogranin rabbit pAb
공급업체: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Acrogranin rabbit pAb |
| Alternative Names | Granulins (Proepithelin; PEPI) [Cleaved into: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:1000–2000; ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human Acrogranin (AA range: 541–590) |
| Species | Rabbit |
| Storage | −20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 2896 |
| Human Swiss-Prot No | P28799 |
| Cellular Localization | Secreted; Lysosome; Endocytosed by SORT1 and delivered to lysosomes (PubMed:21092856, PubMed:28073925). Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (PubMed:26370502, PubMed:28073925). Co-localized with GBA in intracellular trafficking compartments until lysosome (By similarity). |
| Species Reactivity | Human; Rat; Mouse |
Background
- Disease relevance: Defects in GRN cause ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485], also known as tau-negative frontotemporal dementia linked to chromosome 17. FTD is the second most common cause of dementia in people under 65 years and is an autosomal dominant neurodegenerative disease.
- Function: Granulin-4 promotes proliferation of epithelial cell line A431, while granulin-3 acts as an antagonist to granulin-4, inhibiting growth. Granulins may have cytokine-like activity and play roles in inflammation, wound repair, and tissue remodeling.
- PTM: Granulins are disulfide-bridged.
- Similarity: Belongs to the granulin family.
- Tissue specificity: Expressed in myelogenous leukemic cell lines (promonocytic, promyelocytic, proerythroid lineage), fibroblasts, and strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest expression in kidney.
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