ELK Biotechnology SIRT1 (phospho-Ser549) rabbit pAb

제품명

SIRT1 (phospho-Ser549) rabbit pAb

대체 명칭

NAD-dependent protein deacetylase sirtuin-1 (hSIRT1; EC 3.5.1.-; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2)
Cleaved into: SirtT1 75 kDa fragment (75SirT1)

적용 분야 (Applications)

• WB
• ELISA
• IHC

권장 희석 배수 (Recommended Dilutions)

면역원 (Immunogen)

Synthesized peptide derived from human SIRT1 (phospho-Ser549)

보관 및 안정성 (Storage)

• 종(species): Rabbit
• 보관 조건: -20°C, 1년 안정

항체 특성 (Antibody Characteristics)

유전자 정보 (Gene Information)

세포 내 위치 (Cellular Localization)

• Nucleus, PML body, Cytoplasm
• Recruited to nuclear bodies via interaction with PML (PubMed:12006491)
• Colocalized with APEX1 in the nucleus (PubMed:19934257)
• May be found in nucleolus, nuclear euchromatin, heterochromatin, and inner membrane (PubMed:15469825)
• Shuttles between nucleus and cytoplasm (By similarity)
• Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178)
• SirtT1 75 kDa fragment: Cytoplasm, Mitochondrion

배경 (Background)

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been fully determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene belongs to class I of the sirtuin family. Alternative splicing results in multiple transcript variants. (RefSeq, Dec 2008)

반응 종 (Species Reactivity)

• Human
• Mouse