ELK Biotechnology Proteasome α3 rabbit pAb
Proteasome α3 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 IHC에 사용 가능. 사람, 생쥐, 랫트 반응성. 세포질 및 핵에 위치하며, 단백질 분해 복합체 연구에 적합. -20°C에서 1년 보관.
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Proteasome α3 rabbit pAb
제품 개요
Proteasome α3 단백질을 인식하는 토끼 폴리클로날 항체입니다. 단백질 분해 복합체 연구에 유용하며, WB 및 IHC 분석에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Proteasome α3 rabbit pAb |
| Alternative Names | Proteasome subunit alpha type-3 (EC 3.4.25.1; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8) |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human Proteasome α3 (AA range: 190–270) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 5684 |
| Human Swiss-Prot No. | P25788 |
| Cellular Localization | Cytoplasm, Nucleus. Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. |
| Species Reactivity | Human; Mouse; Rat |
Background
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.
An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.
[provided by RefSeq, Jul 2008]
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