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ELK Biotechnology Centaurin-β1 rabbit pAb
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Centaurin-β1 rabbit pAb는 인간, 랫, 마우스 시료에 반응하는 다클론 항체로 WB 및 ELISA에 적합합니다. 인간 Centaurin-β1 유래 펩타이드로 면역화되었으며, 재활용 엔도솜 막 단백질 검출에 유용합니다. 안정적 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology ES20220-100UL Centaurin-β1 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES20220-50UL Centaurin-β1 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Centaurin-β1 rabbit pAb
Centaurin-β1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Centaurin-β1 rabbit pAb |
| Alternative Names | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Centaurin-beta-1; Cnt-b1) |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:1000–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human Centaurin-β1 (AA range: 490–570) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 9744 |
| Human Swiss-Prot No | Q15027 |
| Cellular Localization | Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side |
| Species Reactivity | Human; Rat; Mouse |
Background
- Domain: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2), and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes.
- Enzyme Regulation: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
- Function: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6), required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface.
- Miscellaneous: Cells overexpressing ACAP1 show accumulation of ITGB1 in recycling endosomes and inhibition of stimulation-dependent cell migration. Reduced levels of ACAP1 or AKT1/2 inhibit stimulation-dependent cell migration. Overexpression of ACAP1 and PIP5K1C induces formation of tubular structures derived from endosomal membranes.
- PTM: Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1, export of ITGB1 from recycling endosomes to the cell surface, and ITGB1-dependent cell migration.
- Similarity: Contains 1 Arf-GAP domain, 1 BAR domain, 1 PH domain, and 3 ANK repeats.
- Subunit: Interacts with GTP-bound ARF6, third cytoplasmic loop of SLC2A4/GLUT4, CLTC, and GULP1. Forms a complex with GDP-bound ARF6 and GULP1.
- Tissue Specificity: Highest levels in lung and spleen; low levels in heart, kidney, liver, and pancreas.
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