ELK Biotechnology LRP6 (Phospho Thr1479) rabbit pAb

제품명

LRP6 (Phospho Thr1479) rabbit pAb

기본 정보

세포 내 위치 (Cellular Localization)

Cell membrane; Single-pass type I membrane protein.
Endoplasmic reticulum; Membrane raft.
On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location.
Released from the endoplasmic reticulum on palmitoylation.
Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation.
On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes.
Chaperoned to the plasma membrane by MESD (By similarity).

배경 (Background)

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family.
LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands.
The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade.
Through its interaction with the Wnt/beta-catenin signaling cascade, this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types.
This protein undergoes gamma-secretase dependent RIP (regulated intramembrane proteolysis) processing, but the precise locations of the cleavage sites have not been determined.
[provided by RefSeq, Dec 2009]