ELK Biotechnology RBL2 (Phospho Ser952) rabbit pAb

제품명

RBL2 (Phospho Ser952) rabbit pAb

제품 개요

RBL2 단백질의 Ser952 인산화 부위를 인식하는 토끼 폴리클로날 항체입니다. 세포 주기 조절, 이종염색질 형성, 전사 억제 등의 연구에 활용됩니다.

제품 정보

Background

Function: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure, particularly constitutive heterochromatin, through stabilization of histone methylation. Recruits histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 Lys-20 trimethylation and acts as a transcriptional repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5. Binds to cyclins A and E and may be involved in the transforming capacity of adenovirus E1A protein. May act as a tumor suppressor.

Miscellaneous: G0-restricted expression.

PTM: During G0 and early G1 phases, phosphorylated on Ser-639 and several sites within domain B. Phosphorylation on Ser-672 in G1 leads to ubiquitin-dependent proteolysis.

Similarity: Belongs to the retinoblastoma protein (RB) family.

Subunit: Interacts with AATF, SUV420H1, and SUV420H2. Component of the DREAM complex (also known as LINC complex) composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1, and TFDP2. This complex represses cell cycle-dependent genes in quiescent cells and dissociates in S phase when LIN9, LIN37, LIN52, and LIN54 form a subcomplex that binds to MYBL2. Interacts with RINT1.