ELK Biotechnology RhoA (Phospho Ser188) rabbit pAb
인산화된 RhoA(Ser188)를 인식하는 토끼 다클론 항체로, WB·ELISA·IHC에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며 세포막 및 세포골격 국소화 연구에 유용합니다. 1 mg/ml 농도로 제공되며 -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
RhoA (Phospho Ser188) rabbit pAb
대체 명칭
Transforming protein RhoA (Rho cDNA clone 12; h12)
적용 분야
- WB
- ELISA
- IHC
권장 희석 배율
- WB: 1:500–2000
- IHC-p: 1:50–300
- ELISA: 1:2000–20000
면역원
Synthesized peptide derived from human RhoA (Phospho Ser188)
보관 조건
- 종: Rabbit
- 온도: -20°C
- 유효기간: 1년
클론 특성
| 항목 | 내용 |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| 농도 | 1 mg/ml |
| 관찰 밴드 | 22 kD |
| Gene ID (Human) | 387 |
| Human Swiss-Prot No | P61586 |
세포 내 위치
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex. Midbody. Cell projection, lamellipodium. Cell projection, dendrite. Nucleus.
Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity).
Translocates to the equatorial region before furrow formation in an ECT2-dependent manner.
Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner.
배경 정보
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades.
Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility.
Overexpression of this gene is associated with tumor cell proliferation and metastasis.
Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
반응 종
Human; Mouse; Rat
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