ELK Biotechnology CTIP (Phospho Ser327) rabbit pAb
인산화된 Ser327 부위를 인식하는 CTIP 단백질 특이 토끼 다클론 항체. WB 및 ELISA에 적합하며, 핵 내 DNA 손상 부위에서의 단백질 연구에 유용. 인간 및 생쥐 시료에 반응하며, -20°C에서 1년 보관 가능.
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CTIP (Phospho Ser327) rabbit pAb
제품 개요
이 항체는 인간 CTIP 단백질의 인산화된 Ser327 부위를 인식하는 토끼 다클론 항체입니다. DNA 손상 반응 및 BRCA1 관련 경로 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CTIP (Phospho Ser327) rabbit pAb |
| Alternative Names | DNA endonuclease RBBP8 (EC 3.1.-.-); CtBP-interacting protein; CtIP; Retinoblastoma-binding protein 8; RBBP-8; Retinoblastoma-interacting protein and myosin-like; RIM; Sporulation in the absence of SPO11 protein 2 homolog; SAE2 |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:1000–2000; ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human CTIP (Phospho Ser327) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 100 kDa |
| GeneID (Human) | 5932 |
| Human Swiss-Prot No. | Q99708 |
| Cellular Localization | Nucleus, Chromosome. Associates with sites of DNA damage in S/G2 phase (PubMed:10764811, PubMed:25349192). Ubiquitinated RBBP8 binds to chromatin following DNA damage (PubMed:16818604). |
| Species Reactivity | Human; Mouse |
Background
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly to the retinoblastoma protein, which regulates cell proliferation. This protein complexes with the transcriptional co-repressor CTBP and is associated with BRCA1, playing a role in transcriptional regulation, DNA repair, and cell cycle checkpoint control. It may act as a tumor suppressor in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been identified, with additional variants of undetermined full-length sequences. (RefSeq, Jul 2008)
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