ELK Biotechnology Stat3 (Acetyl Lys685) rabbit pAb
Stat3 (Acetyl Lys685) rabbit polyclonal antibody로, 인간·마우스·랫트 시료에 반응합니다. WB 및 IHC에 사용 가능하며, 세포 내 STAT3 단백질의 아세틸화 상태 분석에 적합합니다. 고특이성 및 재현성 높은 연구용 항체입니다.
- 카탈로그번호
- ES20132-xxxxx (2개 옵션)
- 판매단위
- pk
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Stat3 (Acetyl Lys685) rabbit pAb
제품 개요
Signal transducer and activator of transcription 3 (STAT3)는 세포 내 신호전달 및 유전자 발현 조절에 중요한 역할을 하는 전사인자입니다. 본 항체는 인간 Stat3의 Acetyl Lys685 부위에서 유래한 합성 펩타이드를 면역원으로 제작된 rabbit polyclonal antibody입니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Stat3 (Acetyl Lys685) rabbit pAb |
| Alternative Names | Signal transducer and activator of transcription 3 (Acute-phase response factor) |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human Stat3 (Acetyl Lys685) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 85 kDa |
| Gene ID (Human) | 6774 |
| Human Swiss-Prot No. | P40763 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm and nucleus. Shuttles between the nucleus and cytoplasm. Translocates into the nucleus upon tyrosine phosphorylation and dimerization in response to activated FGFR signaling. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly cytoplasmic without stimuli. Upon LIF stimulation, accumulates in the nucleus. The BART–ARL2 complex is important for nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1. |
Background
Defects in STAT3 cause hyperimmunoglobulin E recurrent infection syndrome (AD-HIES, MIM:147060), also known as hyper-IgE or Job syndrome.
This disorder is characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, elevated serum IgE, eosinophilia, coarse facial features, abnormal dentition, joint hyperextensibility, and bone fractures.
Function:
STAT3 acts as a transcription factor binding to IL-6–responsive elements in acute-phase protein gene promoters and is activated by IL31 via IL31RA. It participates in the gp130-mediated signaling pathway.
Post-translational Modifications (PTM):
- Tyrosine phosphorylation in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-α, and OSM
- Serine phosphorylation upon DNA damage (likely by ATM or ATR), essential for stable DNA-binding homodimer formation and maximal transcriptional activity.
Structure and Interactions:
- Belongs to the STAT family of transcription factors
- Contains one SH2 domain
- Forms homo- or heterodimers (e.g., with STAT1)
- Interacts with NCOA1, PELP1, SOCS7, STATIP1, HCV core protein, IL23R (in presence of IL23), IL31RA, SIPAR, NLK (via SH2 domain), KPNA4, KPNA5, and TMF1
- KPNA4 likely mediates nuclear import
Tissue Specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
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