ELK Biotechnology APOB rabbit pAb

제품명

APOB rabbit pAb

제품 개요

Apolipoprotein B-100 (Apo B-100) 및 그 절단형인 Apolipoprotein B-48 (Apo B-48)을 인식하는 토끼 다클론 항체입니다. 이 항체는 합성된 인간 APOB 유래 펩타이드를 면역원으로 사용하였으며, WB 및 ELISA 분석에 적합합니다.

제품 사양

Background

This gene product is the main apolipoprotein of chylomicrons and low-density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and hepatic forms of apoB are encoded by a single gene from a very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA→UAA), resulting in an early stop codon and truncated translation. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, affecting plasma cholesterol and apoB levels. (RefSeq, Jul 2008)