ELK Biotechnology Smad7 (Acetyl Lys70) rabbit pAb
Smad7 (Acetyl Lys70) rabbit polyclonal antibody로 인간, 마우스, 랫트 시료에 반응. WB 및 IHC에 적합하며, 핵 및 세포질 내 Smad7 단백질 검출에 사용. TGF-β 신호 조절 연구에 활용 가능. -20°C에서 1년 보관.
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Smad7 (Acetyl Lys70) rabbit pAb
제품 개요
Smad7 (Acetyl Lys70) rabbit polyclonal antibody는 인간 Smad7 단백질의 아세틸화된 Lys70 부위를 인식하는 항체입니다. TGF-β 신호 전달 경로 연구 및 Smad7 단백질의 세포 내 위치 분석에 적합합니다.
제품 상세 정보
| 항목 | 내용 |
|---|---|
| Product name | Smad7 (Acetyl Lys70) rabbit pAb |
| Alternative Names | Mothers against decapentaplegic homolog 7 (MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7) |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human Smad7 (Acetyl Lys70) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 4092 |
| Human Swiss-Prot No | O15105 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Nucleus, Cytoplasm. Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits this translocation in response to TGF-beta (PubMed:17327236). |
Background
The protein encoded by the Smad7 gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to degradation of both Smad7 and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are associated with susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been identified.
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