Thermo Fisher Scientific GSTM3 Monoclonal Antibody (20C11.H5.E11)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

Reacts specifically with M3 protein. Cross-reactivity from other sources has not been determined.

Target Information

Glutathione S-transferase M3 (GSTM3) is an enzyme encoded by the GSTM3 gene in humans. It belongs to the mu class of glutathione S-transferases, which function in detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and oxidative stress products, by conjugation with glutathione.

The mu class enzyme genes are organized in a cluster on chromosome 1p13.3 and are highly polymorphic. These genetic variations can influence susceptibility to carcinogens and toxins, as well as the toxicity and efficacy of certain drugs. Mutations in this gene class have been linked with a slight increase in various cancers, likely due to environmental toxin exposure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.