Thermo Fisher Scientific CEACAM1/CEACAM3/CEACAM6 Monoclonal Antibody (YTH71.3)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• This antibody does not react with mouse.
• For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.

Target Information

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster.

The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup.

Multiple cellular activities have been attributed to the encoded protein, including roles in:

• Differentiation and arrangement of tissue three-dimensional structure
• Angiogenesis
• Apoptosis
• Tumor suppression
• Metastasis
• Modulation of innate and adaptive immune responses

Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.