Thermo Fisher Scientific RNF216 Polyclonal Antibody
Human RNF216 단백질에 특이적인 Rabbit Polyclonal Antibody. IHC(P)에서 1:200~1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. NF-κB 신호 조절 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human RNF216. Recombinant protein control fragment (Product #RP-92073) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856277 |
Product Specific Information
Immunogen sequence:
KVIILEEGSL LYTESDPLET QNQSSEDSET ELLSNLGESA ALADDQAIEE DCWLDHPYFQ SLNQQPREIT NQVVPQERQP EAELGRLLFQ HEFPGPAFP
Target Information
Activation of NF-κB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by adapter molecules such as TRIF, TIRAP, and MyD88. Several regulatory mechanisms control TLR signal transduction, including inhibition by molecules such as ST2 and SIGIRR. Another mechanism involves ubiquitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase. TRIAD3A binds to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing their ubiquitination and promoting degradation. Overexpression of TRIAD3A leads to reduced TLR activation, while depletion enhances TLR signaling.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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